Ruthenium carboranyl complexes with 2,2′-bipyridine derivatives for potential bimodal therapy application

Ruthenium complexes of carboranyl ligands offer the possibility of dual action (chemo + radiotherapy) that might result in significant clinical benefits. In that frame, we describe herein the development of ruthenium–carboranyl complexes bearing bipyridyl derivatives.

The bipyridyl derivatives described have the general formula [3-CO-3,3-{κ2-4,4′-R2-2,2′-bipy}-closo-3,1,2-RuC2B9H11] (R = CH3RuCB1 or R = CH2OH, RuCB2). Both compounds crystallized in the monoclinic system, showing the expected three-legged piano stool structure.

The ruthenacarboranes are stable in cell culture media and were tested against two cell lines that have shown favorable clinical responses with BNCT, namely melanoma (A375) and glioblastoma (U87). RuCB1 shows no cytotoxic activity up to 100 μM while RuCB2 showed moderate activity for both cell lines. Cell distribution assays showed that RuCB2 presents high boron internalization that is proportional to the concentration used indicating that RuCB2 presents features to be further studied as a potential anticancer bimodal agent (chemo + radiotherapy).

Ruthenium carboranyl complexes with 2,2′-bipyridine derivatives for potential bimodal therapy application
Ricardo G. Teixeira, Fernanda Marques, M. Paula Robalo, Xavier Fontrodona, M. Helena Garcia, Simonetta Geninatti Crich, Clara Viñas* and Andreia Valente*. 
RSC Adv., 2020, 10, 16266-16276.
DOI: 10.1039/D0RA01522A

Ruthenium carboranyl complexes with 2,2′-bipyridine derivatives for potential bimodal therapy application

Bioactive materials for therapy and diagnosis

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