SCIENTIFIC HIGHLIGHTS

Redox-Active Metallacarborane-Decorated Octasilsesquioxanes. Electrochemical and Thermal Properties
07 January 2017

Polyanionic and electroactive hybrids based on octasilsesquioxanes bearing eight metallacarborane units are developed. The grafting of these metallacarboranes to octavinylsilsesquioxane (OVS) produces an outstanding thermal stability on the final hybrids. Remarkably, these materials exhibit high solubility in organic solvents. Electrochemical studies show that the peripheral metallacarboranes act as independent redox units and simultaneously undergo the redox process, despite the rigid nature of OVS, providing insight into electron transfer in dendrimers.


An ICMAB article selected to be featured in the American Chemical Society Editors' Choice

Hits: 5603
Bioactive materials for therapy and diagnosis

Redox-Active Metallacarborane-Decorated Octasilsesquioxanes. Electrochemical and Thermal Properties



Also at ICMAB

  • Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration

    Information
    13 April 2021 219 hit(s) Biomaterials
    Limbal stem cells (LSCs) are already used in cell‐based treatments for ocular surface disorders. Clinical translation of LSCs‐based therapies critically depends on the successful delivery, survival, and retention of these therapeutic cells to the desired region. Such a major bottleneck could be overcome by using an appropriate carrier to provide anchoring sites and structural support to LSC culture and transplantation.
  • Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

    Information
    02 April 2021 234 hit(s) Biomaterials
    Fabry disease is a rare lysosomal storage disorder characterized by a deficiency of α-galactosidase A (GLA), a lysosomal hydrolase. The enzyme replacement therapy administering naked GLA shows several drawbacks including poor biodistribution, limited efficacy, and relatively high immunogenicity in Fabry patients.An attractive strategy to overcome these problems is the use of nanocarriers for encapsulating the enzyme. Nanoliposomes functionalized with RGD peptide have already emerged as a good platform to protect and deliver GLA to endothelial cells.
  • Radiolabeled Cobaltabis(dicarbollide) Anion–Graphene Oxide Nanocomposites for In Vivo Bioimaging and Boron Delivery

    Information
    23 March 2021 264 hit(s) Biomaterials
    A carbon-based hybrid nanocomposite, which consists of monoiodinated boron-cluster derivatives covalently attached to graphene oxide, is hereby introduced. This GO-I-COSAN has been synthesized using a novel boron-rich cobaltabis(dicarbollide) precursor with one iodide group attached to one of the boron atoms of the cluster (I-COSAN) and designed to be subsequently labeled with radioactive 124I for its use in positron emission tomography (PET).
  • Characterization of crystalline forms of gaxilose, a diagnostic drug

    Information
    17 March 2021 258 hit(s) Biomaterials
    Lactose intolerance is a pathology caused by lactase enzyme deficiency, usually produced in the intestinal cells provoking symptoms as abdominal pain, bloating, diarrhea, gas and nausea. Gaxilose, 4-O-β-D galactopyranosyl-d-xylose, is used as a diagnostic drug for a non-invasive method for hypolactasia diagnosis.

INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA, Copyright © 2020 ICMAB-CSIC | Privacy Policy | This email address is being protected from spambots. You need JavaScript enabled to view it.