SCIENTIFIC HIGHLIGHTS

Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units
25 January 2021
Metalla‐bis‐dicarbollides, such as the cobalta‐bis‐dicarbollide (COSAN) anion [Co(C2B9H11)2], have attracted much attention in biology but a deep understanding of their interactions with cell components is still missing. For this purpose, we studied the interactions of COSAN with the glucose moiety, which is ubiquitous at biological interfaces.
Octyl‐glucopyranoside surfactant (C8G1) was chosen as a model as it self‐assembles in water and creates a hydrated glucose‐covered interface. At low COSAN content and below the critical micellar concentration (CMC) of C8G1, COSAN binds to C8G1 monomers through the hydrophobic effect. Above the CMC of C8G1, COSAN adsorbs onto C8G1 micelles through the superchaotropic effect. At high COSAN concentrations, COSAN disrupts C8G1 micelles and the assemblies become similar to COSAN micelles but with a small amount of solubilized C8G1. Therefore, COSAN binds in a versatile way to C8G1 through either the hydrophobic or superchaotropic effect depending on their relative concentrations.
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Bioactive materials for therapy and diagnosis

Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units


Tania Merhi, Alban Jonchère, Dr. Luc Girard, Dr. Olivier Diat, Miquel Nuez, Prof. Clara Viñas, Dr. Pierre Bauduin

Chem. Eur. J. 2020, 26, 13935
DOI: https://doi.org/10.1002/chem.202002123

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